Endocrine Abstracts

Objectives: To evaluate predictors of permanent, transient and three-phase diabetes insipidus (DI) in patients undergoing endoscopic endonasal transsphenoidal surgery.Patients and methods: The study included 154 patients undergoing endoscopic endonasal transsphenoidal surgery (122 women and 32 men) age from 18 to 65 years (median 40 (31;52)). 73 patients with Cushing disease, 66 patients with acromegaly, four patients with prolactinomas, nine patients wi...

Abstract: Transsphenoidal surgery is the treatment of choice for Cushing’s disease. Despite the 70–90% remission rates relapses after successful transnasal adenectomy are frequently observed.Aim: To evaluate the dynamics of intra- and early postoperative levels of adrenocorticotrophic hormone (ACTH) and cortizol and their role as predictors or Cushing’s disease remission.Materials/methods: Fifty patients with Cushing...

Objective: To assess the levels of osmolality, sodium in blood and urine, and copeptin level in patients after transnasal adenomectomy for pituitary adenomas.Materials and methods: A total of 154 patients, aged 18 to 65 years, were included in this study and underwent transnasal adenomectomy. Surgical treatment was performed in 73 patients with Cushing’s disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inact...

ObjectivesTo assess diagnostic and prognostic markers of permanent and transient postoperative diabetes insipidus.Patients and methodsThe study included 152 patients undergone endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40 [31; 52] years. Seventy three patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inactive adenoma, 1 –...

Objectives: To assess the frequencies of hyponatremia and central diabetes insipidus (CDI) after transnasal adenomectomy and to identify its risk factors.Patients and methods: The study included 152 patients aged 18 to 65 years (median [Q1; Q3] 40 [31; 52]) who underwent endoscopic endonasal transsphenoidal surgery due to Cushing’s disease, acromegaly, prolactinoma, non-functioning pituitary adenoma, thyreotropinoma or Nelson’s syndrome at Endo...

Introduction: Water-electrolyte disorders are serious complications after transnasal adenomectomy for formations of the hypothalamic-pituitary region. The purpose of this work was to evaluate the incidence of postoperative hyponatremia in the tactics of active control of sodium levels in the blood.Materials and methods: The study included the results of a dynamic study of blood sodium levels in 53 patients (mean age 46.6 years [min 19; max 68]) with pitu...

Introduction: According to recent studies, fluid and electrolyte disturbances complicate the course of transnasal adenomectomy for pituitary adenomas in 13–30% of cases and are associated with a high risk of neurological complications and increased mortality. Neuropeptides discovered in recent decades (apelin, copeptin, oxytocin, brain natriuretic peptide) in many studies demonstrate their significant effect on the regulation of water-electrolyte metabolism, which makes t...

Objective: To estimate the outcome of neurosurgery in patients with Cushing’s disease (CD) with and without pituitary adenoma visualisation on MRI.Material and methods: Patients with confirmed CD (11.2008–11.2014) by both inferior petrosal sinus sampling (IPSS) and histological evaluation after neurosurgery were enrolled into the study. Subjects were referred for IPSS because of non-visualised pituitary adenoma or contradictory results of non-i...

The course and predictors of postoperative diabetes insipidus.Objectives: To evaluate the course and predictors of permanent and transient postoperative diabetes insipidus (DI).Patients and Methods: The study included 152 patients undergoing endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40. 73 patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inacti...